Neuronal circuitry for recognition memory of object and place in rodent models

Yuan Hsin Chao, Susanne Nikolaus, Yi Mei Yang, Joseph P. Huston

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations

Abstract

Rats and mice are used for studying neuronal circuits underlying recognition memory due to their ability to spontaneously remember the occurrence of an object, its place and an association of the object and place in a particular environment. A joint employment of lesions, pharmacological interventions, optogenetics and chemogenetics is constantly expanding our knowledge of the neural basis for recognition memory of object, place, and their association. In this review, we summarize current studies on recognition memory in rodents with a focus on the novel object preference, novel location preference and object-in-place paradigms. The evidence suggests that the medial prefrontal cortex- and hippocampus-connected circuits contribute to recognition memory for object and place. Under certain conditions, the striatum, medial septum, amygdala, locus coeruleus and cerebellum are also involved. We propose that the neuronal circuitry for recognition memory of object and place is hierarchically connected and constructed by different cortical (perirhinal, entorhinal and retrosplenial cortices), thalamic (nucleus reuniens, mediodorsal and anterior thalamic nuclei) and primeval (hypothalamus and interpeduncular nucleus) modules interacting with the medial prefrontal cortex and hippocampus.

Original languageEnglish (US)
Article number104855
JournalNeuroscience and Biobehavioral Reviews
Volume141
DOIs
StatePublished - Oct 2022

Bibliographical note

Funding Information:
We acknowledge funding support by the National Institute of Neurological Disorders and Stroke (NINDS) of the National Institutes of Health (NIH) grant R15NS112964 to YMY, the Winston and Maxine Wallin Neuroscience Discovery Fund to YMY, the Academic Investment Research Program-Individual Principal Investigator Award AIRP2-IND-67 to YMY, and the Brain & Behavior Research Foundation (BBRF) Young Investigator Grant ( 29192 ) to OYC.

Publisher Copyright:
© 2022 Elsevier Ltd

Keywords

  • Cell type specificity
  • Entorhinal cortex
  • Hippocampus
  • Medial prefrontal cortex
  • Object recognition
  • Spatial memory
  • Thalamus

PubMed: MeSH publication types

  • Journal Article
  • Review
  • Research Support, Non-U.S. Gov't
  • Research Support, N.I.H., Extramural

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