Neuronal activity and outcomes from thalamic surgery for spinocerebellar ataxia

Takao Hashimoto, Abirami Muralidharan, Kunihiro Yoshida, Tetsuya Goto, Takehiro Yako, Kenneth B. Baker, Jerrold L. Vitek

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Objectives: We investigated the effects of deep brain stimulation (DBS) or lesions of the ventral intermediate nucleus (Vim) of the thalamus for spinocerebellar ataxia (SCA) and examined the pathophysiological role of neuronal activity of the Vim underlying ataxia. Methods: Five patients with SCA with cortical atrophy (ages 60-69 years; 2 sporadic and three familial SCA) and five patients with essential tremor (ET) (ages 57–71 years) were treated with Vim surgery. Intraoperatively, we recorded neuronal activity from single neurons in the Vim thalamus while patients were at rest and compared the physiological properties of those neurons between patients with SCA and those with ET. Results: Postsurgery mean scores for the Fahn–Tolosa–Marin Tremor Scale were improved from 78 to 44 in SCA patients and from 54 to 21 in ET patients. Stronger stimulation was necessary to optimize outcomes in SCA as compared to ET patients. We analyzed 68 Vim neurons in SCA and 60 Vim neurons in ET. Mean discharge rates, burst characteristics, and oscillatory activity were similar for both patient groups, however, we observed that the ratio of cells responding to passive manipulation was significantly smaller (P = 0.0001) in SCA (22%) than in ET (71%). Interpretation: Thalamic surgery led to a significant improvement in tremor in SCA patients. One potential mechanism underlying ataxia in SCA may be disruption of cerebellar sensory feedback, which modulates motor commands in the cerebello-thalamo-cortical network.

Original languageEnglish (US)
Pages (from-to)52-63
Number of pages12
JournalAnnals of Clinical and Translational Neurology
Volume5
Issue number1
DOIs
StatePublished - Jan 2018

Bibliographical note

Funding Information:
K.Y. is funded by a research grant from the Research Committee of the Ataxia, Research on Policy Planning and Evaluation for Rare and Intractable Diseases, Health and Labour Sciences Research Grants, The Ministry of Health, Labour and Welfare, Japan.

Funding Information:
J.L.V. has received research funding from the NIH, Boston Scientific, Medtronic, and Abbott. He is also a consultant for Boston Scientific, Medtronic, InSightec, and Abbott and a scientific advisor for Surgical Information Systems. All other authors declare no conflict of interest.

Publisher Copyright:
© 2017 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association.

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