Neuromodulation of cognition in Parkinson's disease

Rachel C. Cole, Derrick N. Okine, Brooke E. Yeager, Nandakumar S. Narayanan

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations


Neuromodulation is a widely used treatment for motor symptoms of Parkinson's disease (PD). It can be a highly effective treatment as a result of knowledge of circuit dysfunction associated with motor symptoms in PD. However, the mechanisms underlying cognitive symptoms of PD are less well-known, and the effects of neuromodulation on these symptoms are less consistent. Nonetheless, neuromodulation provides a unique opportunity to modulate motor and cognitive circuits while minimizing off-target side effects. We review the modalities of neuromodulation used in PD and the potential implications for cognitive symptoms. There have been some encouraging findings with both invasive and noninvasive modalities of neuromodulation, and there are promising advances being made in the field of therapeutic neuromodulation. Substantial work is needed to determine which modulation targets are most effective for the different types of cognitive deficits of PD.

Original languageEnglish (US)
Title of host publicationCognition in Parkinson's Disease
EditorsNandakumar S. Narayanan, Roger L. Albin, Roger L. Albin
PublisherElsevier B.V.
Number of pages21
ISBN (Print)9780323901642
StatePublished - Jan 2022
Externally publishedYes

Publication series

NameProgress in Brain Research
ISSN (Print)0079-6123
ISSN (Electronic)1875-7855

Bibliographical note

Publisher Copyright:
© 2022 Elsevier B.V.


  • Basal ganglia
  • Deep brain stimulation
  • Movement disorders
  • Nonmotor symptoms
  • Prefrontal cortex
  • Transcranial alternating current stimulation
  • Transcranial direct current stimulation
  • Transcranial magnetic stimulation


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