Neuromodulation for brain disorders: Challenges and opportunities

Matthew D. Johnson; Hubert H. Lim; Theoden I. Netoff; Allison T. Connolly; Nessa Johnson; Abhrajeet Roy; Abbey Holt; Kelvin O. Lim; James R. Carey; Jerrold L. Vitek; Bin He

doi:10.1109/TBME.2013.2244890

Neuromodulation for brain disorders: Challenges and opportunities

Matthew D. Johnson, Hubert H. Lim, Theoden I. Netoff, Allison T. Connolly, Nessa Johnson, Abhrajeet Roy, Abbey Holt, Kelvin O. Lim, James R. Carey, Jerrold L. Vitek, Bin He

Research output: Contribution to journal › Review article › peer-review

177 Scopus citations

Abstract

The field of neuromodulation encompasses a wide spectrum of interventional technologies that modify pathological activity within the nervous system to achieve a therapeutic effect. Therapies including deep brain stimulation, intracranial cortical stimulation, transcranial direct current stimulation, and transcranial magnetic stimulation have all shown promising results across a range of neurological and neuropsychiatric disorders. While the mechanisms of therapeutic action are invariably different among these approaches, there are several fundamental neuroengineering challenges that are commonly applicable to improving neuromodulation efficacy. This paper reviews the state-of-the-art of neuromodulation for brain disorders and discusses the challenges and opportunities available for clinicians and researchers interested in advancing neuromodulation therapies.

Original language	English (US)
Pages (from-to)	610-624
Number of pages	15
Journal	IEEE Transactions on Biomedical Engineering
Volume	60
Issue number	3
DOIs	https://doi.org/10.1109/TBME.2013.2244890
State	Published - 2013

Keywords

Deep brain stimulation (DBS)
Intracranial cortical stimulation (ICS)
Neuroengineering
Neuromodulation
Transcranial direct current stimulation (tDCS)
Transcranial magnetic stimulation (TMS)

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10.1109/TBME.2013.2244890

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abstract = "The field of neuromodulation encompasses a wide spectrum of interventional technologies that modify pathological activity within the nervous system to achieve a therapeutic effect. Therapies including deep brain stimulation, intracranial cortical stimulation, transcranial direct current stimulation, and transcranial magnetic stimulation have all shown promising results across a range of neurological and neuropsychiatric disorders. While the mechanisms of therapeutic action are invariably different among these approaches, there are several fundamental neuroengineering challenges that are commonly applicable to improving neuromodulation efficacy. This paper reviews the state-of-the-art of neuromodulation for brain disorders and discusses the challenges and opportunities available for clinicians and researchers interested in advancing neuromodulation therapies.",

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AU - Johnson, Nessa

AU - Roy, Abhrajeet

AU - Holt, Abbey

AU - Lim, Kelvin O.

AU - Carey, James R.

AU - Vitek, Jerrold L.

AU - He, Bin

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KW - Intracranial cortical stimulation (ICS)

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Neuromodulation for brain disorders: Challenges and opportunities

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