Neuromedin U octapeptide alters ion transport in porcine jejunum

David R. Brown, Francis L. Quito

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The gut neuropeptide, neuromedin U octapeptide (NMU-8) produced transient elevations in short-circuit current (EC50 = 0.7 nmol/1) after its contraluminal administration to sheets of porcine distal jejunal mucosa in vitro. Mucosal responses to NMU-8 were unaffected by 1 μmol/1 atropine or hexamethonium, but were abolished by tetrodotoxin (0.1 μmol/l), dependent upon extracellular Cl, and underwent tachyphylaxis upon repeated peptide application. NMU-8 did not affect contractility of isolated jejunal longitudinal muscle. Thus, NMU-8 appears to selectively modify intestinal ion transport through interactions with non-cholinergic enteric neurons.

Original languageEnglish (US)
Pages (from-to)159-162
Number of pages4
JournalEuropean Journal of Pharmacology
Issue number1-2
StatePublished - Oct 11 1988

Bibliographical note

Funding Information:
The authors thank Ward A. Ortman for excellent technical assistance in performing smooth muscle bioassays. This work was funded in part by Minnesota Agricultural Experiment Station Grant MN-061-37 and National Institutes of Health Grant DK-37497.


  • (Longitudinal muscle, Contractility, Pig)
  • Enteric nervous system
  • Intestinal ion transport
  • Jejunum (distal)
  • Neuromedin U


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