Neurohormonal upregulation modulates vascular tone as well as salt and water retention as important adaptive responses to cardiac insufficiency. In recent decades, neurohormonal blockade has been the foundation of several standard drugs therapies of heart failure, but disappointing attempts to modulate these neurohormonal systems further have highlighted the complexity of the original neurohormonal hypothesis, and point to a need to examine more critically the clinical roles of combining existing and new neurohormonal antagonists in the treatment of heart failure.
|Original language||English (US)|
|Number of pages||9|
|Journal||Heart Failure Clinics|
|State||Published - Apr 2005|