Neurohormonal Upregulation in Heart Failure

W. H. Wilson Tang, Gary S. Francis

Research output: Contribution to journalReview articlepeer-review

10 Scopus citations


Neurohormonal upregulation modulates vascular tone as well as salt and water retention as important adaptive responses to cardiac insufficiency. In recent decades, neurohormonal blockade has been the foundation of several standard drugs therapies of heart failure, but disappointing attempts to modulate these neurohormonal systems further have highlighted the complexity of the original neurohormonal hypothesis, and point to a need to examine more critically the clinical roles of combining existing and new neurohormonal antagonists in the treatment of heart failure.

Original languageEnglish (US)
Pages (from-to)1-9
Number of pages9
JournalHeart Failure Clinics
Issue number1
StatePublished - Apr 2005

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Copyright 2011 Elsevier B.V., All rights reserved.

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