Neurofilament function and dysfunction: involvement in axonal growth and neuronal disease

Michael K. Lee, Don W. Cleveland

Research output: Contribution to journalArticlepeer-review

122 Scopus citations

Abstract

Neurofilaments make up the major intermediate filament system in mature neurons. Recent studies demonstrate that neurofilaments in vivo are obligate heteropolymers and are required for proper radial growth of axons. Furthermore, forced over-expression of neurofilament subunits in transgenic mice shows that abnormal accumulation and assembly of neurofilaments, similar to that commonly found in human motor neuron disease, can directly cause motor neuron dysfunction.

Original languageEnglish (US)
Pages (from-to)34-40
Number of pages7
JournalCurrent Opinion in Cell Biology
Volume6
Issue number1
DOIs
StatePublished - Feb 1994

Keywords

  • ALS
  • CDK
  • NF
  • amyotrophic lateral sclerosis
  • cyclin-dependent kinase
  • neurofilament

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