Neurodevelopment of the zebrafish spinal serotonin system

Mark A. Masino, Jacob E. Montgomery

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Serotonin performs a wide range of physiological functions, both within and outside of the nervous system. In the spinal cord, serotonergic signaling modulates sensory and locomotor network activity and influences various neurodevelopmental processes. The largest source of spinal serotonin in mammals is the caudal raphe nuclei that project from the hindbrain to the spinal cord; however, vertebrates also possess intraspinal serotonergic neurons that project locally within the spinal cord. The number, location, and innervation patterns of the intraspinal serotonergic neurons are variable between species, with mammals possessing relatively few compared to fish and amphibians. In the zebrafish embryo, a subset of cerebrospinal fluid-contacting neurons located below the central canal are the sole source of serotonergic innervation of the spinal cord. During the transition to the larval developmental stage, these cells lose their serotonergic phenotype and are replaced by descending serotonergic raphe axons and a second, persistent population of intraspinal serotonergic neurons. This chapter details the progression of gene expression and spinal innervation patterns in these developing serotonergic cell populations.

Original languageEnglish (US)
Title of host publicationDiagnosis, Management and Modeling of Neurodevelopmental Disorders
Subtitle of host publicationThe Neuroscience of Development
PublisherElsevier
Pages533-543
Number of pages11
ISBN (Electronic)9780128179888
ISBN (Print)9780128179895
DOIs
StatePublished - Jan 1 2021

Bibliographical note

Publisher Copyright:
© 2021 Elsevier Inc. All rights reserved.

Keywords

  • 5-HT
  • Cerebrospinal fluid
  • Development
  • Pet1
  • Raphe
  • Serotonergic
  • Serotonin
  • Spinal cord
  • Tryptophan hydroxylase
  • Zebrafish

Fingerprint

Dive into the research topics of 'Neurodevelopment of the zebrafish spinal serotonin system'. Together they form a unique fingerprint.

Cite this