Abstract
Transcranial alternating current stimulation (tACS) can modulate human neural activity and behavior. Accordingly, tACS has vast potential for cognitive research and brain disorder therapies. The stimulation generates oscillating electric fields in the brain that can bias neural spike timing, causing changes in local neural oscillatory power and cross-frequency and cross-area coherence. tACS affects cognitive performance by modulating underlying single or nested brain rhythms, local or distal synchronization, and metabolic activity. Clinically, stimulation tailored to abnormal neural oscillations shows promising results in alleviating psychiatric and neurological symptoms. We summarize the findings of tACS mechanisms, its use for cognitive applications, and novel developments for personalized stimulation.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 189-205 |
| Number of pages | 17 |
| Journal | Trends in Cognitive Sciences |
| Volume | 27 |
| Issue number | 2 |
| DOIs | |
| State | Published - Feb 2023 |
Bibliographical note
Funding Information:This work was supported by the Brain and Behavior Research Foundation (young investigator grant to I.A.), the University of Minnesota MnDrive Initiative (M.W. and A.O.), and the National Institute of Mental Health (grants RF1MH124909 to A.O. and K99MH128454 to I.A.).
Publisher Copyright:
© 2022 The Authors
Keywords
- cognitive performance
- neural oscillations
- neuromodulation
- non-invasive brain stimulation
- transcranial alternating current stimulation
- transcranial brain stimulation