Neurocognitive domains affected by cerebral malaria and severe malarial anemia in children

Paul Bangirana; Robert O. Opoka; Michael J. Boivin; Richard Idro; James S Hodges; Chandy C. John

doi:10.1016/j.lindif.2015.01.010

Neurocognitive domains affected by cerebral malaria and severe malarial anemia in children

Paul Bangirana, Robert O. Opoka, Michael J. Boivin, Richard Idro, James S Hodges, Chandy C. John

Research output: Contribution to journal › Article › peer-review

43 Scopus citations

Abstract

This study assessed the effects of cerebral malaria (CM) and severe malarial anemia (SMA) on individual neurocognitive domains. Eighty children with CM, 86 with SMA, and 61 community children (CC) were assessed for gross motor skills, fine motor skills, visual reception, receptive language, and expressive language a week after discharge (CM or SMA) or at enrolment (CC), and 6 and 12 months later. At 12-months follow-up, children with CM had significantly lower scores than CC for all outcomes. Children with SMA had significantly lower scores than CC for visual reception, receptive language, and expressive language, and scores that were lower but did not reach significance for gross and fine motor skills. Children with CM had significantly lower scores than children with SMA for fine motor skills. Children with SMA and CM have long-term impairment in multiple neurocognitive domains. Fine motor skills may be affected more profoundly in CM than SMA.

Original language	English (US)
Pages (from-to)	38-44
Number of pages	7
Journal	Learning and Individual Differences
Volume	46
DOIs	https://doi.org/10.1016/j.lindif.2015.01.010
State	Published - Feb 1 2016

Bibliographical note

Funding Information:
This work was supported by the National Institute of Neurological Disorders and Stroke (grant number R01NS055349 ) and the Fogarty International Center (grant number D43 NS078280 ). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. The funding source had no role in the study design; in the collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit the article for publication.

Keywords

Cerebral malaria
Neurocognitive deficits
Severe malarial anemia

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.lindif.2015.01.010

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abstract = "This study assessed the effects of cerebral malaria (CM) and severe malarial anemia (SMA) on individual neurocognitive domains. Eighty children with CM, 86 with SMA, and 61 community children (CC) were assessed for gross motor skills, fine motor skills, visual reception, receptive language, and expressive language a week after discharge (CM or SMA) or at enrolment (CC), and 6 and 12 months later. At 12-months follow-up, children with CM had significantly lower scores than CC for all outcomes. Children with SMA had significantly lower scores than CC for visual reception, receptive language, and expressive language, and scores that were lower but did not reach significance for gross and fine motor skills. Children with CM had significantly lower scores than children with SMA for fine motor skills. Children with SMA and CM have long-term impairment in multiple neurocognitive domains. Fine motor skills may be affected more profoundly in CM than SMA.",

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note = "Funding Information: This work was supported by the National Institute of Neurological Disorders and Stroke (grant number R01NS055349 ) and the Fogarty International Center (grant number D43 NS078280 ). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. The funding source had no role in the study design; in the collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit the article for publication. ",

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AU - Hodges, James S

AU - John, Chandy C.

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PY - 2016/2/1

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N2 - This study assessed the effects of cerebral malaria (CM) and severe malarial anemia (SMA) on individual neurocognitive domains. Eighty children with CM, 86 with SMA, and 61 community children (CC) were assessed for gross motor skills, fine motor skills, visual reception, receptive language, and expressive language a week after discharge (CM or SMA) or at enrolment (CC), and 6 and 12 months later. At 12-months follow-up, children with CM had significantly lower scores than CC for all outcomes. Children with SMA had significantly lower scores than CC for visual reception, receptive language, and expressive language, and scores that were lower but did not reach significance for gross and fine motor skills. Children with CM had significantly lower scores than children with SMA for fine motor skills. Children with SMA and CM have long-term impairment in multiple neurocognitive domains. Fine motor skills may be affected more profoundly in CM than SMA.

AB - This study assessed the effects of cerebral malaria (CM) and severe malarial anemia (SMA) on individual neurocognitive domains. Eighty children with CM, 86 with SMA, and 61 community children (CC) were assessed for gross motor skills, fine motor skills, visual reception, receptive language, and expressive language a week after discharge (CM or SMA) or at enrolment (CC), and 6 and 12 months later. At 12-months follow-up, children with CM had significantly lower scores than CC for all outcomes. Children with SMA had significantly lower scores than CC for visual reception, receptive language, and expressive language, and scores that were lower but did not reach significance for gross and fine motor skills. Children with CM had significantly lower scores than children with SMA for fine motor skills. Children with SMA and CM have long-term impairment in multiple neurocognitive domains. Fine motor skills may be affected more profoundly in CM than SMA.

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Neurocognitive domains affected by cerebral malaria and severe malarial anemia in children

Abstract

Bibliographical note

Keywords

UN SDGs

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