Neurocognitive and neuroimaging correlates of pediatric traumatic brain injury: A diffusion tensor imaging (DTI) study

Jeffrey R. Wozniak, Linda Krach, Erin Ward, Bryon A. Mueller, Ryan Muetzel, Sarah Schnoebelen, Andrew Kiragu, Kelvin O. Lim

Research output: Contribution to journalArticlepeer-review

254 Scopus citations


This study examined the sensitivity of diffusion tensor imaging (DTI) to microstructural white matter (WM) damage in mild and moderate pediatric traumatic brain injury (TBI). Fourteen children with TBI and 14 controls ages 10-18 had DTI scans and neurocognitive evaluations at 6-12 months post-injury. Groups did not differ in intelligence, but children with TBI showed slower processing speed, working memory and executive deficits, and greater behavioral dysregulation. The TBI group had lower fractional anisotropy (FA) in three WM regions: inferior frontal, superior frontal, and supracallosal. There were no group differences in corpus callosum. FA in the frontal and supracallosal regions was correlated with executive functioning. Supracallosal FA was also correlated with motor speed. Behavior ratings showed correlations with supracallosal FA. Parent-reported executive deficits were inversely correlated with FA. Results suggest that DTI measures are sensitive to long-term WM changes and associated with cognitive functioning following pediatric TBI.

Original languageEnglish (US)
Pages (from-to)555-568
Number of pages14
JournalArchives of Clinical Neuropsychology
Issue number5
StatePublished - Jun 2007

Bibliographical note

Funding Information:
The authors would like to thank Rosemary Froehle for assistance with subject recruitment and data collection at Hennepin County Medical Center as well as Andrea Nugent for assistance in recruitment and data collection at Gillette Children's Specialty Healthcare. Funding and research support was provided by the National Academy of Neuropsychology and the National Institutes of Health—P41RR008079 and P30NS057091.


  • Diffusion tensor imaging (DTI)
  • Pediatric
  • Traumatic brain injury (TBI)
  • White matter


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