Neurobiology of estrogen status in deep craniofacial pain

David A Bereiter, Keiichiro Okamoto

Research output: Chapter in Book/Report/Conference proceedingChapter

20 Scopus citations

Abstract

Pain in the temporomandibular joint (TMJ) region often occurs with no overt signs of injury or inflammation. Although the etiology of TMJ-related pain may involve multiple factors, one likely risk factor is female gender or estrogen status. Evidence is reviewed from human and animal studies, supporting the proposition that estrogen status acts peripherally or centrally to influence TMJ nociceptive processing. A new model termed the "TMJ pain matrix" is proposed as critical for the initial integration of TMJ-related sensory signals in the lower brainstem that is both modified by estrogen status, and closely linked to endogenous pain and autonomic control pathways.

Original languageEnglish (US)
Title of host publicationInternational Review of Neurobiology
PublisherAcademic Press Inc.
Pages251-284
Number of pages34
DOIs
StatePublished - 2011

Publication series

NameInternational Review of Neurobiology
Volume97
ISSN (Print)0074-7742
ISSN (Electronic)0074-7742

Keywords

  • Craniofacial
  • Estrogen
  • Neurobiology
  • Pain control
  • Peripheral
  • Temporomandibular

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  • Cite this

    Bereiter, D. A., & Okamoto, K. (2011). Neurobiology of estrogen status in deep craniofacial pain. In International Review of Neurobiology (pp. 251-284). (International Review of Neurobiology; Vol. 97). Academic Press Inc.. https://doi.org/10.1016/B978-0-12-385198-7.00010-2