Neuroanatomical correlates of morphine dependence

Eddie Wei, Horace H. Loh, E. Leong Way

Research output: Contribution to journalArticlepeer-review

76 Scopus citations

Abstract

Naloxone hydrochloride, an opioid antagonist, was applied to several discrete brain regions of morphine-dependent rats to precipitate abstinence. Severe withdrawal signs were elicited after administration in the thalamus but not in neocortical, hippocampal, hypothalamic, or tegmental areas of the brain.

Original languageEnglish (US)
Pages (from-to)616-617
Number of pages2
JournalScience
Volume177
Issue number4049
DOIs
StatePublished - Jan 1 1972

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