Neuro-oncologic applications of exosomes, microvesicles, and other nano-sized extracellular particles

David D. Gonda, Johnny C. Akers, Ryan Kim, Steven N. Kalkanis, Fred H. Hochberg, Clark C. Chen, Bob S. Carter

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

The discovery that tumor-derived proteins and nucleic acids can be detected in nano-sized vesicles in the plasma and cerebrospinal fluid of patients afflicted with brain tumors has expanded opportunities for biomarker and therapeutic discovery. Through delivery of their contents to surrounding cells, exosomes, microvesicles, and other nano-sized extracellular vesicles secreted by tumors modulate their environment to promote tumor growth and survival. In this review, we discuss the biological processes mediated by these extracellular vesicles and their applications in terms of brain tumor diagnosis, monitoring, and therapy. We review the normal physiology of these extracellular vesicles, their pertinence to tumor biology, and directions for research in this field.

Original languageEnglish (US)
Pages (from-to)501-510
Number of pages10
JournalNeurosurgery
Volume72
Issue number4
DOIs
StatePublished - Apr 2013

Keywords

  • Biomarkers
  • Exosomes
  • Extracellular vesicles
  • Microvesicles

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