Neural repair and neuroprotection with stem cells in ischemic stroke

Research output: Contribution to journalReview articlepeer-review

16 Scopus citations


Stem cells have been touted as a potential source of cells for repair in regenerative medicine. When transplanted into the central nervous system, stem cells have been shown to differentiate into neurons and glia. Recent studies, however, have also revealed neuroprotective properties of stem cells. These studies suggest that various types of stem cells are able to protect against the loss of neurons in conditions of ischemic brain injury. In this article, we discuss the use of stem cells for ischemic stroke and the parameters under which neuroprotection can occur in the translation of stem cell therapy to the clinical setting.

Original languageEnglish (US)
Pages (from-to)599-614
Number of pages16
JournalBrain Sciences
Issue number2
StatePublished - Jun 2013


  • Ischemia
  • Ischemic brain injury
  • Neuroprotection
  • Stem cells
  • Stroke


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