@inproceedings{2fcd26fd683a42158b1b11d6970753a4,
title = "Neural probes for concurrent detection of neurochemical and electrophysiological signals in vivo",
abstract = "Electrochemical sensing with microelectrode arrays provides a means for monitoring neurotransmitter dynamics across multiple locations within a micro-scale region of brain tissue. Here we present a multi-modal neural probe design for concurrent recording of neurochemical and electro-physiological signals in vivo. Prior to implantation, platinum sites on each array underwent platinum-black electroplating and Nafion electropolymerization, which increased sensitivity to dopamine by 74% and decreased sensitivity to common interferents by at least 89%. In a series of three rats, we applied various electrochemical waveforms to platinum sites and monitored neural activity on adjacent iridium sites. We found that chronoamperometry and constant-potential amperometry did not alter firing rates at +0.25, +0.50, and +0.75 V. In addition, we have demonstrated multi-modal recordings of striatal neurons in response to medial forebrain bundle stimulation.",
keywords = "Chemical sensing, Dopamine, Microelectrodes, Neural probe, Neural recordings",
author = "Johnson, {M. D.} and Franklin, {R. K.} and Scott, {K. A.} and Brown, {R. B.} and Kipke, {D. R.}",
year = "2005",
doi = "10.1109/iembs.2005.1616203",
language = "English (US)",
isbn = "0780387406",
series = "Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings",
publisher = "Institute of Electrical and Electronics Engineers Inc.",
pages = "7325--7328",
booktitle = "Proceedings of the 2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005",
note = "2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005 ; Conference date: 01-09-2005 Through 04-09-2005",
}