Reality monitoring is the ability to accurately distinguish the source of self-generated information from externally-presented information. Although people with schizophrenia (SZ) show impaired reality monitoring, nothing is known about how mood state influences this higher-order cognitive process. Accordingly, we induced positive, neutral and negative mood states to test how different mood states modulate subsequent reality monitoring performance. Our findings indicate that mood affected reality monitoring performance in HC and SZ participants in both similar and dissociable ways. Only a positive mood facilitated task performance in Healthy Control (HC) subjects, whereas a negative mood facilitated task performance in SZ subjects. Yet, when both HC and SZ participants were in a positive mood, they recruited medial prefrontal cortex (mPFC) to bias better subsequent self-generated item identification, despite the fact that mPFC signal was reduced in SZ participants. Additionally, in SZ subjects, negative mood states also modulated left and right dorsal mPFC signal to bias better externally-presented item identification. Together our findings reveal that although the mPFC is hypoactive in SZ participants, mPFC signal plays a functional role in mood–cognition interactions during both positive and negative mood states to facilitate subsequent reality monitoring decision-making.
Bibliographical noteFunding Information:
This research was supported by the Brain and Behavior Research Foundation Young Investigator Award grant (NARSAD: 17680) and NIMH K01 grant (KO1MH82818) to Karuna Subramaniam, and the following NIH grants to Srikantan Nagarajan and Sophia Vinogradov (R01DC004855, R01DC010145, R21NS076171, R01MH068725 and R01DC013979). None of the authors have financial disclosures to declare. We thank Zarinah Agnew and Naomi Kort for their assistance and input on this project.
- Medial prefrontal cortex
- Positive mood induction
- Reality monitoring
- Source memory