Neural mechanisms of hyperalgesia

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Abstract

Hyperalgesia, or enhanced sensitivity to pain, is a symptom often associated with inflammation, nerve injury and various diseases. Although hyperalgesia appears to be mediated by sensitization of peripheral and central pain-signalling neurons, underlying mechanisms of sensitization are not well understood. Recent contributions to our knowledge of the mechanisms underlying hyperalgesia and sensitization are reviewed.

Original languageEnglish (US)
Pages (from-to)479-483
Number of pages5
JournalCurrent opinion in neurobiology
Volume2
Issue number4
DOIs
StatePublished - Aug 1992

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