TY - JOUR
T1 - Neural mechanisms of hyperalgesia
AU - Simone, Donald A.
PY - 1992/8
Y1 - 1992/8
N2 - Hyperalgesia, or enhanced sensitivity to pain, is a symptom often associated with inflammation, nerve injury and various diseases. Although hyperalgesia appears to be mediated by sensitization of peripheral and central pain-signalling neurons, underlying mechanisms of sensitization are not well understood. Recent contributions to our knowledge of the mechanisms underlying hyperalgesia and sensitization are reviewed.
AB - Hyperalgesia, or enhanced sensitivity to pain, is a symptom often associated with inflammation, nerve injury and various diseases. Although hyperalgesia appears to be mediated by sensitization of peripheral and central pain-signalling neurons, underlying mechanisms of sensitization are not well understood. Recent contributions to our knowledge of the mechanisms underlying hyperalgesia and sensitization are reviewed.
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U2 - 10.1016/0959-4388(92)90183-L
DO - 10.1016/0959-4388(92)90183-L
M3 - Article
C2 - 1525546
AN - SCOPUS:0026904728
SN - 0959-4388
VL - 2
SP - 479
EP - 483
JO - Current opinion in neurobiology
JF - Current opinion in neurobiology
IS - 4
ER -