Neural interaction in control of adrenocorticotropin

Multiple afferent pathways underlie the control of adrenocorticotropin (ACTH). The variety of sensory stimuli that elicit ACTH release indicate that neural interaction and convergence within the central nervous system contribute to this control system. The site and nature of neural interactions contributing to ACTH release are unknown. However, recent evidence suggests that some of the sensory convergence and temporal plasticity within the system that controls ACTH release may exist at the brain-stem level. Within the hypothalamus, different areas may preferentially activate the release of different releasing factors so that additional convergence and interaction may occur within the median eminence or the pituitary.