Neural ensembles in CA3 transiently encode paths forward of the animal at a decision point

Adam Johnson, A. David Redish

    Research output: Contribution to journalArticle

    521 Scopus citations

    Abstract

    Neural ensembles were recorded from the CA3 region of rats running on T-based decision tasks. Examination of neural representations of space at fast time scales revealed a transient but repeatable phenomenon as rats made a decision: the location reconstructed from the neural ensemble swept forward, first down one path and then the other. Estimated representations were coherent and preferentially swept ahead of the animal rather than behind the animal, implying it represented future possibilities rather than recently traveled paths. Similar phenomena occurred at other important decisions (such as in recovery from an error). Local field potentials from these sites contained pronounced theta and gamma frequencies, but no sharp wave frequencies. Forward-shifted spatial representations were influenced by task demands and experience. These data suggest that the hippocampus does not represent space as a passive computation, but rather that hippocampal spatial processing is an active process likely regulated by cognitive mechanisms.

    Original languageEnglish (US)
    Pages (from-to)12176-12189
    Number of pages14
    JournalJournal of Neuroscience
    Volume27
    Issue number45
    DOIs
    StatePublished - Nov 7 2007

    Keywords

    • Cognition
    • Decision making
    • Hippocampus
    • Neural ensemble
    • Place cell
    • Vicarious trial
    • Visual error

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