Neural Crest Cells and Cancer. Insights into Tumor Progression.

Davalyn R. Powell; Jenean H. O'Brien; Heide L. Ford; Kristin Bruk Artinger

doi:10.1016/B978-0-12-401730-6.00017-X

Neural Crest Cells and Cancer. Insights into Tumor Progression.

Davalyn R. Powell, Jenean H. O'Brien, Heide L. Ford, Kristin Bruk Artinger

Research output: Chapter in Book/Report/Conference proceeding › Chapter

4 Scopus citations

Abstract

Neural crest cells (NCC) and tumor cells undergo remarkably similar cellular and molecular changes during the progression from an epithelial cell to a migratory mesenchymal-like cell in the course of embryonic development and metastatic disease, respectively. Many of the same genes and genetic pathways are expressed and required for delamination, migration, survival, and proliferation to occur in both neural crest and cancer. Additionally, tumors that originate from NCC and their derivatives exhibit re-activation and/or misregulation of genes that were expressed during normal development and differentiation. These parallels make neural crest development an excellent model for understanding the pathways tumor cells may employ during cancer progression and may provide clues to improve cancer diagnosis, treatment, and therapies.

Original language	English (US)
Title of host publication	Neural Crest Cells
Subtitle of host publication	Evolution, Development and Disease
Publisher	Elsevier Inc.
Pages	335-357
Number of pages	23
ISBN (Print)	9780124017306
DOIs	https://doi.org/10.1016/B978-0-12-401730-6.00017-X
State	Published - 2014
Externally published	Yes

Keywords

Epithelial-to-mesenchymal transition
Glioma
Melanoma
Migration
Neuroblastoma

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/B978-0-12-401730-6.00017-X

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title = "Neural Crest Cells and Cancer. Insights into Tumor Progression.",

abstract = "Neural crest cells (NCC) and tumor cells undergo remarkably similar cellular and molecular changes during the progression from an epithelial cell to a migratory mesenchymal-like cell in the course of embryonic development and metastatic disease, respectively. Many of the same genes and genetic pathways are expressed and required for delamination, migration, survival, and proliferation to occur in both neural crest and cancer. Additionally, tumors that originate from NCC and their derivatives exhibit re-activation and/or misregulation of genes that were expressed during normal development and differentiation. These parallels make neural crest development an excellent model for understanding the pathways tumor cells may employ during cancer progression and may provide clues to improve cancer diagnosis, treatment, and therapies.",

keywords = "Epithelial-to-mesenchymal transition, Glioma, Melanoma, Migration, Neuroblastoma",

author = "Powell, {Davalyn R.} and O'Brien, {Jenean H.} and Ford, {Heide L.} and Artinger, {Kristin Bruk}",

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language = "English (US)",

isbn = "9780124017306",

pages = "335--357",

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TY - CHAP

T1 - Neural Crest Cells and Cancer. Insights into Tumor Progression.

AU - Powell, Davalyn R.

AU - O'Brien, Jenean H.

AU - Ford, Heide L.

AU - Artinger, Kristin Bruk

PY - 2014

Y1 - 2014

N2 - Neural crest cells (NCC) and tumor cells undergo remarkably similar cellular and molecular changes during the progression from an epithelial cell to a migratory mesenchymal-like cell in the course of embryonic development and metastatic disease, respectively. Many of the same genes and genetic pathways are expressed and required for delamination, migration, survival, and proliferation to occur in both neural crest and cancer. Additionally, tumors that originate from NCC and their derivatives exhibit re-activation and/or misregulation of genes that were expressed during normal development and differentiation. These parallels make neural crest development an excellent model for understanding the pathways tumor cells may employ during cancer progression and may provide clues to improve cancer diagnosis, treatment, and therapies.

AB - Neural crest cells (NCC) and tumor cells undergo remarkably similar cellular and molecular changes during the progression from an epithelial cell to a migratory mesenchymal-like cell in the course of embryonic development and metastatic disease, respectively. Many of the same genes and genetic pathways are expressed and required for delamination, migration, survival, and proliferation to occur in both neural crest and cancer. Additionally, tumors that originate from NCC and their derivatives exhibit re-activation and/or misregulation of genes that were expressed during normal development and differentiation. These parallels make neural crest development an excellent model for understanding the pathways tumor cells may employ during cancer progression and may provide clues to improve cancer diagnosis, treatment, and therapies.

KW - Epithelial-to-mesenchymal transition

KW - Glioma

KW - Melanoma

KW - Migration

KW - Neuroblastoma

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U2 - 10.1016/B978-0-12-401730-6.00017-X

DO - 10.1016/B978-0-12-401730-6.00017-X

M3 - Chapter

AN - SCOPUS:84902431526

SN - 9780124017306

SP - 335

EP - 357

BT - Neural Crest Cells

PB - Elsevier Inc.

ER -

Neural Crest Cells and Cancer. Insights into Tumor Progression.

Abstract

Keywords

UN SDGs

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