Neural correlates of lower limbs proprioception: An fMRI study of foot position matching

Riccardo Iandolo, Alessandro Bellini, Catarina Saiote, Ilaria Marre, Giulia Bommarito, Niels Oesingmann, Lazar Fleysher, Giovanni Luigi Mancardi, Maura Casadio, Matilde Inglese

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Little is known about the neural correlates of lower limbs position sense, despite the impact that proprioceptive deficits have on everyday life activities, such as posture and gait control. We used fMRI to investigate in 30 healthy right-handed and right-footed subjects the regional distribution of brain activity during position matching tasks performed with the right dominant and the left nondominant foot. Along with the brain activation, we assessed the performance during both ipsilateral and contralateral matching tasks. Subjects had lower errors when matching was performed by the left nondominant foot. The fMRI analysis suggested that the significant regions responsible for position sense are in the right parietal and frontal cortex, providing a first characterization of the neural correlates of foot position matching.

Original languageEnglish (US)
Pages (from-to)1929-1944
Number of pages16
JournalHuman Brain Mapping
Volume39
Issue number5
DOIs
StatePublished - May 2018

Bibliographical note

Funding Information:
The authors would like to thank Filippo Sante and Giorgio Carlini for their help during the development of the MR compatible device.

Funding Information:
Marie Curie Integration Grant REMAKE, Grant/Award Number: FP7-PEOPLE-2012- CIG-334201; National Multiple Sclerosis Society, Grant/Award Number: NMSS RG 5120A3/1

Funding Information:
Dr Matilde Inglese has received research grants from NIH, NMSS, DOD, and Teva Neuroscience. Dr Gianluigi Mancardi has received honoraria for lecturing, travel expenses for attending meetings, and financial support for research from Bayer Schering, Biogen Idec, Genzyme, Merck Serono, Novartis, Sanofi-Aventis, and Teva Pharmaceuticals. Dr Maura Casadio was supported by by Marie Curie Integration Grant (REMAKE, FP7-PEOPLE-2012-CIG-334201). Riccardo Iandolo, Alessandro Bellini, Catarina Saiote, Giulia Bommarito, Ilaria Marre, Lazar Fleysher, and Niels Oesingmann have nothing to disclose.

Publisher Copyright:
© 2018 Wiley Periodicals, Inc.

Keywords

  • fMRI
  • matching task
  • motor control
  • position sense
  • proprioception
  • sensory feedback

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