Neural correlates of encoding and expression in implicit sequence learning

R. D. Seidler, A. Purushotham, S. G. Kim, K. Ugurbil, D. Willingham, J. Ashe

Research output: Contribution to journalArticlepeer-review

99 Scopus citations

Abstract

In the domain of motor learning it has been difficult to separate the neural substrate of encoding from that of change in performance. Consequently, it has not been clear whether motor effector areas participate in learning or merely modulate changes in performance. Here, using a variant of the serial reaction time task that dissociated these two factors, we report that encoding during procedural motor learning does engage cortical motor areas and can be characterized by distinct early and late encoding phases. The highest correlation between activation and subsequent changes in motor performance was seen in the motor cortex during early encoding, and in the basal ganglia during the late encoding phase. Our results show that rapid encoding during procedural motor learning involves several distinct processes, and is represented primarily within motor system structures.

Original languageEnglish (US)
Pages (from-to)114-124
Number of pages11
JournalExperimental Brain Research
Volume165
Issue number1
DOIs
StatePublished - Aug 2005

Bibliographical note

Funding Information:
Acknowledgements Supported by NIH grants NS40106, MH065598, and RR08079, the Department of Veterans Affairs, and the American Legion Chair in Brain Sciences.

Keywords

  • Implicit learning
  • Motor cortex
  • Motor performance
  • Sequence Learning
  • Serial reaction time

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