Neural basis of orexigenic effects of ghrelin acting within lateral hypothalamus

Pawel K. Olszewski, Dehong Li, Martha K. Grace, Charles J. Billington, Catherine M. Kotz, Allen S. Levine

Research output: Contribution to journalArticlepeer-review

112 Scopus citations

Abstract

Ghrelin stimulates feeding when administered centrally and peripherally. The lateral hypothalamus (LH) is thought to mediate ghrelin-induced hyperphagia. Thus, we examined central mechanisms underlying feeding generated by LH ghrelin. We determined that 0.3nmol of LH-injected ghrelin was the lowest dose increasing food consumption and it induced Fos immunoreactivity (IR; a marker of neuronal activation) in feeding-related brain areas, including the hypothalamic paraventricular, arcuate, and dorsomedial nuclei, amygdala, and nucleus of the solitary tract. Also, LH ghrelin induced Fos IR in LH orexin neurons. We conclude that the LH, as part of larger central circuitry, integrates orexigenic properties of ghrelin.

Original languageEnglish (US)
Pages (from-to)597-602
Number of pages6
JournalPeptides
Volume24
Issue number4
DOIs
StatePublished - Apr 1 2003

Keywords

  • Arcuate nucleus
  • Central nucleus of the amygdala
  • Dorsomedial nucleus of the hypothalamus
  • Food intake
  • Fos
  • Ghrelin
  • Hypocretin
  • Immunohistochemistry
  • Lateral hypothalamus
  • Nucleus of the solitary tract
  • Orexin
  • Paraventricular nucleus of the hypothalamus

Fingerprint Dive into the research topics of 'Neural basis of orexigenic effects of ghrelin acting within lateral hypothalamus'. Together they form a unique fingerprint.

Cite this