Nephrotoxicity of Cyclosporine

B. D. Kahan, C. t.Van Buren, C. A. Wideman, D. A. Cooley, O. H. Frazier, Uwe J. Hesse, David E.r. Sutherland, S. Michael Mauer, John S. Najarian, Robert M. Merion, David J.g. White, Robert W. Griffith, Peter A. Woodbridge, Joe C. Rutledge, Bryan D. Myers, Jon Ross, Lynn Newton, John Luetscher, Mark Perlroth

Research output: Contribution to journalLetter

5 Citations (Scopus)

Abstract

To the Editor: In the September 13 issue of the Journal, Myers and co-workers1cite our work2 to support the statement that “the dose was reduced thereafter to maintain trough plasma levels of immunoassayable cyclosporine slightly above a putative immunosuppressive threshold of 200 ng per milliliter.” In fact, both the cited article and the previous, more specific publication addressing trough levels3 state that 200 ng per milliliter represents the threshold for nephrotoxicity. Recipients of renal allografts who have abnormal renal function due to drug-induced nephrotoxicity generally have trough levels above 200 ng per milliliter as determined in serum by.

Original languageEnglish (US)
Pages (from-to)48-50
Number of pages3
JournalNew England Journal of Medicine
Volume312
Issue number1
DOIs
StatePublished - Jan 3 1985

Fingerprint

Cyclosporine
Kidney
Immunosuppressive Agents
Allografts
Publications
Serum
Pharmaceutical Preparations

Cite this

Kahan, B. D., Buren, C. T. V., Wideman, C. A., Cooley, D. A., Frazier, O. H., Hesse, U. J., ... Perlroth, M. (1985). Nephrotoxicity of Cyclosporine. New England Journal of Medicine, 312(1), 48-50. https://doi.org/10.1056/NEJM198501033120112

Nephrotoxicity of Cyclosporine. / Kahan, B. D.; Buren, C. t.Van; Wideman, C. A.; Cooley, D. A.; Frazier, O. H.; Hesse, Uwe J.; Sutherland, David E.r.; Mauer, S. Michael; Najarian, John S.; Merion, Robert M.; White, David J.g.; Griffith, Robert W.; Woodbridge, Peter A.; Rutledge, Joe C.; Myers, Bryan D.; Ross, Jon; Newton, Lynn; Luetscher, John; Perlroth, Mark.

In: New England Journal of Medicine, Vol. 312, No. 1, 03.01.1985, p. 48-50.

Research output: Contribution to journalLetter

Kahan, BD, Buren, CTV, Wideman, CA, Cooley, DA, Frazier, OH, Hesse, UJ, Sutherland, DER, Mauer, SM, Najarian, JS, Merion, RM, White, DJG, Griffith, RW, Woodbridge, PA, Rutledge, JC, Myers, BD, Ross, J, Newton, L, Luetscher, J & Perlroth, M 1985, 'Nephrotoxicity of Cyclosporine', New England Journal of Medicine, vol. 312, no. 1, pp. 48-50. https://doi.org/10.1056/NEJM198501033120112
Kahan BD, Buren CTV, Wideman CA, Cooley DA, Frazier OH, Hesse UJ et al. Nephrotoxicity of Cyclosporine. New England Journal of Medicine. 1985 Jan 3;312(1):48-50. https://doi.org/10.1056/NEJM198501033120112
Kahan, B. D. ; Buren, C. t.Van ; Wideman, C. A. ; Cooley, D. A. ; Frazier, O. H. ; Hesse, Uwe J. ; Sutherland, David E.r. ; Mauer, S. Michael ; Najarian, John S. ; Merion, Robert M. ; White, David J.g. ; Griffith, Robert W. ; Woodbridge, Peter A. ; Rutledge, Joe C. ; Myers, Bryan D. ; Ross, Jon ; Newton, Lynn ; Luetscher, John ; Perlroth, Mark. / Nephrotoxicity of Cyclosporine. In: New England Journal of Medicine. 1985 ; Vol. 312, No. 1. pp. 48-50.
@article{96c6d52d4f3f492e8da2d16f8bd17477,
title = "Nephrotoxicity of Cyclosporine",
abstract = "To the Editor: In the September 13 issue of the Journal, Myers and co-workers1cite our work2 to support the statement that “the dose was reduced thereafter to maintain trough plasma levels of immunoassayable cyclosporine slightly above a putative immunosuppressive threshold of 200 ng per milliliter.” In fact, both the cited article and the previous, more specific publication addressing trough levels3 state that 200 ng per milliliter represents the threshold for nephrotoxicity. Recipients of renal allografts who have abnormal renal function due to drug-induced nephrotoxicity generally have trough levels above 200 ng per milliliter as determined in serum by.",
author = "Kahan, {B. D.} and Buren, {C. t.Van} and Wideman, {C. A.} and Cooley, {D. A.} and Frazier, {O. H.} and Hesse, {Uwe J.} and Sutherland, {David E.r.} and Mauer, {S. Michael} and Najarian, {John S.} and Merion, {Robert M.} and White, {David J.g.} and Griffith, {Robert W.} and Woodbridge, {Peter A.} and Rutledge, {Joe C.} and Myers, {Bryan D.} and Jon Ross and Lynn Newton and John Luetscher and Mark Perlroth",
year = "1985",
month = "1",
day = "3",
doi = "10.1056/NEJM198501033120112",
language = "English (US)",
volume = "312",
pages = "48--50",
journal = "New England Journal of Medicine",
issn = "0028-4793",
publisher = "Massachussetts Medical Society",
number = "1",

}

TY - JOUR

T1 - Nephrotoxicity of Cyclosporine

AU - Kahan, B. D.

AU - Buren, C. t.Van

AU - Wideman, C. A.

AU - Cooley, D. A.

AU - Frazier, O. H.

AU - Hesse, Uwe J.

AU - Sutherland, David E.r.

AU - Mauer, S. Michael

AU - Najarian, John S.

AU - Merion, Robert M.

AU - White, David J.g.

AU - Griffith, Robert W.

AU - Woodbridge, Peter A.

AU - Rutledge, Joe C.

AU - Myers, Bryan D.

AU - Ross, Jon

AU - Newton, Lynn

AU - Luetscher, John

AU - Perlroth, Mark

PY - 1985/1/3

Y1 - 1985/1/3

N2 - To the Editor: In the September 13 issue of the Journal, Myers and co-workers1cite our work2 to support the statement that “the dose was reduced thereafter to maintain trough plasma levels of immunoassayable cyclosporine slightly above a putative immunosuppressive threshold of 200 ng per milliliter.” In fact, both the cited article and the previous, more specific publication addressing trough levels3 state that 200 ng per milliliter represents the threshold for nephrotoxicity. Recipients of renal allografts who have abnormal renal function due to drug-induced nephrotoxicity generally have trough levels above 200 ng per milliliter as determined in serum by.

AB - To the Editor: In the September 13 issue of the Journal, Myers and co-workers1cite our work2 to support the statement that “the dose was reduced thereafter to maintain trough plasma levels of immunoassayable cyclosporine slightly above a putative immunosuppressive threshold of 200 ng per milliliter.” In fact, both the cited article and the previous, more specific publication addressing trough levels3 state that 200 ng per milliliter represents the threshold for nephrotoxicity. Recipients of renal allografts who have abnormal renal function due to drug-induced nephrotoxicity generally have trough levels above 200 ng per milliliter as determined in serum by.

UR - http://www.scopus.com/inward/record.url?scp=0021931324&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021931324&partnerID=8YFLogxK

U2 - 10.1056/NEJM198501033120112

DO - 10.1056/NEJM198501033120112

M3 - Letter

C2 - 3964907

AN - SCOPUS:0021931324

VL - 312

SP - 48

EP - 50

JO - New England Journal of Medicine

JF - New England Journal of Medicine

SN - 0028-4793

IS - 1

ER -