Nephrotoxicity of continuous intravenous infusion of recombinant interleukin-2

Neal P. Christiansen, Keith M Skubitz, Karl Nath, Augusto Ochoa, B. J. Kennedy

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

Adoptive immunotherapy with recombinant interleukin-2 has been complicated by significant nephrotoxicity of uncertain etiology. Creatinine clearance, effective renal plasma flow, plasma renin activity, aldosterone levels, and urinary prostaglandin excretion were evaluated in a 62-year-old man receiving continuous infusion recombinant interleukin-2. There was a marked decrease in the creatinine clearance and renal plasma flow, accompanied by an elevation in plasma renin activity and aldosterone level. Prostaglandin excretion also decreased, implying a direct effect on renal prostaglandin synthesis. The decrease in renal prostaglandin synthesis at a time of increased plasma renin activity may explain the reduction in renal function seen with recombinant interleukin-2 therapy.

Original languageEnglish (US)
Pages (from-to)1072-1075
Number of pages4
JournalThe American Journal of Medicine
Volume84
Issue number6
DOIs
StatePublished - Jun 1988

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