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Nephrotoxicity due to intermediate-dose methotrexate without rescue in an obese adolescent with acute lymphoblastic leukemia

  • Martin Sauer
  • , Nancy Rydholm
  • , John Piatkowski
  • , Victor Lewis
  • , Marie Steiner

Research output: Contribution to journal › Article › peer-review

Abstract

Toxicity from intermediate-dose methotrexate (MTX) is unusual. A severely obese adolescent with acute lymphoblastic leukemia experienced significant, delayed nephrotoxicity from intermediate-dose MTX. Altered MTX disposition may occur as a consequence of other ingestions or conditions such as obesity. The use of radioisotope renography established the diagnosis and followed the resolution of the patient's MTX-induced nephrotoxicity.

Original languageEnglish (US)
Pages (from-to)135-140
Number of pages6
JournalPediatric hematology and oncology
Volume19
Issue number2
DOIs
StatePublished - 2002

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

  1. SDG 3 - Good Health and Well-being
    SDG 3 Good Health and Well-being

Keywords

  • Acute lymphoblastic leukemia
  • Methotrexate
  • Nephrotoxicity
  • Obesity
  • Renogram

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