Nephrotoxicity due to intermediate-dose methotrexate without rescue in an obese adolescent with acute lymphoblastic leukemia

Martin Sauer, Nancy Rydholm, John Piatkowski, Victor Lewis, Marie Steiner

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Toxicity from intermediate-dose methotrexate (MTX) is unusual. A severely obese adolescent with acute lymphoblastic leukemia experienced significant, delayed nephrotoxicity from intermediate-dose MTX. Altered MTX disposition may occur as a consequence of other ingestions or conditions such as obesity. The use of radioisotope renography established the diagnosis and followed the resolution of the patient's MTX-induced nephrotoxicity.

Original languageEnglish (US)
Pages (from-to)135-140
Number of pages6
JournalPediatric hematology and oncology
Volume19
Issue number2
DOIs
StatePublished - 2002

Keywords

  • Acute lymphoblastic leukemia
  • Methotrexate
  • Nephrotoxicity
  • Obesity
  • Renogram

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