Nephroprotective action of peucedanum grande against cadmium chloride induced renal toxicity in Wistar rats

Mohammad Aslam, Shiekh Tanveer Ahmad, Rameshver Dayal, Kalim Javid, Sadiq Umar, Asia Asiaf, Sana Nafees, Jalal Uddin Bhat, Arjumand Wani, Mohammad Samim, Surender Singh

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Cadmium is a known industrial pollutant which accumulates in the kidney and its exposure leads to the production of reactive oxygen species (ROS). The present study was carried out to evaluate the protective effects of Peucedanum grande against CdCl 2 induced renal toxicity in Wistar rats. Wistar rats were subjected to oral pre-treatment of P. grande (60 and 120 mg/kg b.wt) against the renal toxicity induced by administration of CdCl 2 (3mg/kg b.wt). Efficacy of P. grande against the renal toxicity was evaluated in terms of biochemical estimation of antioxidant enzyme activities and histopathological changes. P. grande pretreatment prevented deteriorative effects induced by CdCl 2 through a protective mechanism that involved reduction of increased oxidative stress as well as by restoration of histopathological changes against CdCl 2 administration.

Original languageEnglish (US)
Pages (from-to)444-452
Number of pages9
JournalEXCLI Journal
Volume11
StatePublished - 2012

Keywords

  • Cadmium chloride
  • Nephrotoxicity
  • Peucedanum grande
  • ROS

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