Abstract
Prenatal exposure of rats to 0.2 mg LAAM/kg/day but not to 0.05 mg LAAM/kg/day resulted in faster hot-plate escape latencies in 6 mo old offspring. No differences in tail-flick latencies were observed at 7 mo of age in offspring exposed to either dose of LAAM prenatally. Subsequent testing of littermates at 16 mo of age revealed that the greater sensitivity to the hot-plate observed in rats prenatally exposed to LAAM is apparently a result of neonatal withdrawal rather than a primary consequence of the drug. The data are discussed in relation to possible effects of drug or withdrawal on central nervous system development.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1725-1730 |
| Number of pages | 6 |
| Journal | Life Sciences |
| Volume | 34 |
| Issue number | 18 |
| DOIs | |
| State | Published - Apr 30 1984 |
Bibliographical note
Funding Information:This research was supported in part by United States Public Health Service Grant DA01880.
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