Neonatal opiate withdrawal alters the reactivity of adult rats to the hot-plate

L. Lichtblau, R. B. Messing, S. B. Sparber

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Prenatal exposure of rats to 0.2 mg LAAM/kg/day but not to 0.05 mg LAAM/kg/day resulted in faster hot-plate escape latencies in 6 mo old offspring. No differences in tail-flick latencies were observed at 7 mo of age in offspring exposed to either dose of LAAM prenatally. Subsequent testing of littermates at 16 mo of age revealed that the greater sensitivity to the hot-plate observed in rats prenatally exposed to LAAM is apparently a result of neonatal withdrawal rather than a primary consequence of the drug. The data are discussed in relation to possible effects of drug or withdrawal on central nervous system development.

Original languageEnglish (US)
Pages (from-to)1725-1730
Number of pages6
JournalLife Sciences
Issue number18
StatePublished - Apr 30 1984

Bibliographical note

Funding Information:
This research was supported in part by United States Public Health Service Grant DA01880.


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