Neonatal opiate withdrawal alters the reactivity of adult rats to the hot-plate

L. Lichtblau; R. B. Messing; S. B. Sparber

doi:10.1016/0024-3205(84)90571-X

Neonatal opiate withdrawal alters the reactivity of adult rats to the hot-plate

L. Lichtblau, R. B. Messing, S. B. Sparber

Basic Sciences

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8 Scopus citations

Abstract

Prenatal exposure of rats to 0.2 mg LAAM/kg/day but not to 0.05 mg LAAM/kg/day resulted in faster hot-plate escape latencies in 6 mo old offspring. No differences in tail-flick latencies were observed at 7 mo of age in offspring exposed to either dose of LAAM prenatally. Subsequent testing of littermates at 16 mo of age revealed that the greater sensitivity to the hot-plate observed in rats prenatally exposed to LAAM is apparently a result of neonatal withdrawal rather than a primary consequence of the drug. The data are discussed in relation to possible effects of drug or withdrawal on central nervous system development.

Original language	English (US)
Pages (from-to)	1725-1730
Number of pages	6
Journal	Life Sciences
Volume	34
Issue number	18
DOIs	https://doi.org/10.1016/0024-3205(84)90571-X
State	Published - Apr 30 1984

Bibliographical note

Funding Information:
This research was supported in part by United States Public Health Service Grant DA01880.

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title = "Neonatal opiate withdrawal alters the reactivity of adult rats to the hot-plate",

abstract = "Prenatal exposure of rats to 0.2 mg LAAM/kg/day but not to 0.05 mg LAAM/kg/day resulted in faster hot-plate escape latencies in 6 mo old offspring. No differences in tail-flick latencies were observed at 7 mo of age in offspring exposed to either dose of LAAM prenatally. Subsequent testing of littermates at 16 mo of age revealed that the greater sensitivity to the hot-plate observed in rats prenatally exposed to LAAM is apparently a result of neonatal withdrawal rather than a primary consequence of the drug. The data are discussed in relation to possible effects of drug or withdrawal on central nervous system development.",

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T1 - Neonatal opiate withdrawal alters the reactivity of adult rats to the hot-plate

AU - Lichtblau, L.

AU - Messing, R. B.

AU - Sparber, S. B.

N1 - Funding Information: This research was supported in part by United States Public Health Service Grant DA01880.

PY - 1984/4/30

Y1 - 1984/4/30

N2 - Prenatal exposure of rats to 0.2 mg LAAM/kg/day but not to 0.05 mg LAAM/kg/day resulted in faster hot-plate escape latencies in 6 mo old offspring. No differences in tail-flick latencies were observed at 7 mo of age in offspring exposed to either dose of LAAM prenatally. Subsequent testing of littermates at 16 mo of age revealed that the greater sensitivity to the hot-plate observed in rats prenatally exposed to LAAM is apparently a result of neonatal withdrawal rather than a primary consequence of the drug. The data are discussed in relation to possible effects of drug or withdrawal on central nervous system development.

AB - Prenatal exposure of rats to 0.2 mg LAAM/kg/day but not to 0.05 mg LAAM/kg/day resulted in faster hot-plate escape latencies in 6 mo old offspring. No differences in tail-flick latencies were observed at 7 mo of age in offspring exposed to either dose of LAAM prenatally. Subsequent testing of littermates at 16 mo of age revealed that the greater sensitivity to the hot-plate observed in rats prenatally exposed to LAAM is apparently a result of neonatal withdrawal rather than a primary consequence of the drug. The data are discussed in relation to possible effects of drug or withdrawal on central nervous system development.

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Neonatal opiate withdrawal alters the reactivity of adult rats to the hot-plate

Abstract

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