Neonatal cholestasis-conjugated hyperbilirubinemia

Chad M. Best, Glenn R. Gourley, Vinod K. Bhutani

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


Jaundice during the first few weeks of life is a common finding. Frequently, such jaundice is due to elevation of the unconjugated, or indirect bilirubin, and is often the result of a benign process. More concerning is jaundice due to elevation of the conjugated bilirubin fraction. Neonatal cholestasis is defined as an accumulation of biliary substances, such as bilirubin and bile acids because of impaired canalicular bile flow. Neonatal cholestasis manifests with a conjugated hyperbilirubinemia and must be differentiated from unconjugated hyperbilirubinemia, as it is more often associated with a specific disease process. The incidence of neonatal cholestasis has been estimated at 1 in 2500 live births [1].

Original languageEnglish (US)
Title of host publicationNeonatology
Subtitle of host publicationA Practical Approach to Neonatal Diseases
PublisherSpringer-Verlag Milan
Number of pages9
ISBN (Electronic)9788847014053
ISBN (Print)9788847014046
StatePublished - Jan 1 2012


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