Neonatal Acute Liver Failure

Catherine Larson-Nath, Bernadette E. Vitola

Research output: Contribution to journalReview articlepeer-review

13 Scopus citations


Neonatal acute liver failure (NALF) is a rare disease with a few known primary causes: gestational alloimmune liver disease (GALD), viral infections, metabolic diseases, and ischemic injury. Many cases still do not have a known cause. Laboratory evaluation may suggest a diagnosis. Most of the known causes have disease-specific treatments that improve outcomes. Survival is improving with better knowledge about and treatment options for GALD; however, overall mortality for NALF is still 24%. Liver transplant remains an important option for neonates with an indeterminate cause of NALF and those who do not respond to established treatments.

Original languageEnglish (US)
Pages (from-to)25-39
Number of pages15
JournalClinics in Perinatology
Issue number1
StatePublished - Mar 2020

Bibliographical note

Publisher Copyright:
© 2019 Elsevier Inc.

Copyright 2020 Elsevier B.V., All rights reserved.


  • Gestational alloimmune liver disease
  • Liver failure
  • Liver transplant
  • Neonatal

PubMed: MeSH publication types

  • Journal Article
  • Review


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