Neoadjuvant chemotherapy (NACT) is an effective way of managing elderly women with advanced stage ovarian cancer (FIGO Stage IIIC and IV)

Michelle A Glasgow, Herbert Yu, Thomas J. Rutherford, Masoud Azodi, Dan Arin Silasi, Alessandro D. Santin, Peter E. Schwartz

Research output: Contribution to journalArticlepeer-review

40 Scopus citations

Abstract

Background: To compare outcomes in women ≥ age 70 who receive neoadjuvant chemotherapy (NACT) for advanced epithelial ovarian cancer (EOC) followed by cytoreductive surgery with those undergoing upfront cytoreductive surgery followed by the same chemotherapy. Methods: A retrospective cohort study was performed for women ≥ age 70 with Stage IIIC or Stage IV EOC from 1996 to 2009. Results: Sixty-two patients who underwent upfront cytoreductive surgery and 42 patients who received NACT were eligible for analysis. Patients receiving NACT were significantly more likely to have Stage IV disease (P = 0.004). Cytoreduction to no macroscopic disease was achieved in 71.4% of women who received NACT and 28.1% of women undergoing upfront surgery (P < 0.001). NACT patients had significantly less blood loss at surgery (P = 0.01), required fewer small bowel resections (P = 0.009), had shorter ICU stays (P = 0.02) and fewer hospital days (P = 0.04). NACT patients experienced a trend toward an improved progression-free survival (P = 0.078); however, no statistically significant differences were found in either the progression-free or overall survival analyses. Conclusion NACT is associated with reduced perioperative morbidity in elderly patients with advanced stage ovarian cancer.

Original languageEnglish (US)
Pages (from-to)195-200
Number of pages6
JournalJournal of Surgical Oncology
Volume107
Issue number2
DOIs
StatePublished - Feb 1 2013

Keywords

  • elderly women
  • neoadjuvant chemotherapy
  • ovarian carcinoma
  • survival analysis

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