Neglect, HPA axis reactivity, and development

Emily B. Reilly, Megan R. Gunnar

Research output: Contribution to journalReview articlepeer-review

28 Scopus citations


Neglect is a common and frequently chronic form of child maltreatment that can compromise child development and increase the risk of physical and psychological problems. In this review, we discuss one of the potential ways neglect becomes biologically embedded by shaping the development of a key stress responsive system: namely, the hypothalamic-pituitary-adrenal (HPA) axis. Several potential mediators and moderators of this process are examined, including inflammation, attachment and social buffering, self-regulation, child sex and age, and genetics.

Original languageEnglish (US)
Pages (from-to)100-108
Number of pages9
JournalInternational Journal of Developmental Neuroscience
StatePublished - Nov 2019


  • Child development
  • HPA axis
  • Neglect

PubMed: MeSH publication types

  • Journal Article
  • Review


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