Negatively-charged helices in the gas phase

Andrew R. Johnson; Jonathan M. Dilger; Matthew S. Glover; David E. Clemmer; Erin E. Carlson

doi:10.1039/c4cc03257h

Negatively-charged helices in the gas phase

Andrew R. Johnson, Jonathan M. Dilger, Matthew S. Glover, David E. Clemmer, Erin E. Carlson

Chemistry (Twin Cities)

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

A polyalanine-based peptide which forms a stable, negatively-charged α-helix in the gas phase is reported. Addition of an N-terminal acidic residue forms a stabilizing hydrogen bond network and an electrostatic interaction with the helical dipole. Formation of this secondary structure was demonstrated using ion mobility-mass spectrometry and molecular modelling techniques.

Original language	English (US)
Pages (from-to)	8849-8851
Number of pages	3
Journal	Chemical Communications
Volume	50
Issue number	64
DOIs	https://doi.org/10.1039/c4cc03257h
State	Published - Jul 15 2014

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10.1039/c4cc03257h

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title = "Negatively-charged helices in the gas phase",

abstract = "A polyalanine-based peptide which forms a stable, negatively-charged α-helix in the gas phase is reported. Addition of an N-terminal acidic residue forms a stabilizing hydrogen bond network and an electrostatic interaction with the helical dipole. Formation of this secondary structure was demonstrated using ion mobility-mass spectrometry and molecular modelling techniques.",

author = "Johnson, {Andrew R.} and Dilger, {Jonathan M.} and Glover, {Matthew S.} and Clemmer, {David E.} and Carlson, {Erin E.}",

year = "2014",

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doi = "10.1039/c4cc03257h",

language = "English (US)",

volume = "50",

pages = "8849--8851",

journal = "Chemical Communications",

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publisher = "Royal Society of Chemistry",

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T1 - Negatively-charged helices in the gas phase

AU - Johnson, Andrew R.

AU - Dilger, Jonathan M.

AU - Glover, Matthew S.

AU - Clemmer, David E.

AU - Carlson, Erin E.

PY - 2014/7/15

Y1 - 2014/7/15

N2 - A polyalanine-based peptide which forms a stable, negatively-charged α-helix in the gas phase is reported. Addition of an N-terminal acidic residue forms a stabilizing hydrogen bond network and an electrostatic interaction with the helical dipole. Formation of this secondary structure was demonstrated using ion mobility-mass spectrometry and molecular modelling techniques.

AB - A polyalanine-based peptide which forms a stable, negatively-charged α-helix in the gas phase is reported. Addition of an N-terminal acidic residue forms a stabilizing hydrogen bond network and an electrostatic interaction with the helical dipole. Formation of this secondary structure was demonstrated using ion mobility-mass spectrometry and molecular modelling techniques.

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UR - http://www.scopus.com/inward/citedby.url?scp=84904438057&partnerID=8YFLogxK

U2 - 10.1039/c4cc03257h

DO - 10.1039/c4cc03257h

M3 - Article

C2 - 24901462

AN - SCOPUS:84904438057

SN - 1359-7345

VL - 50

SP - 8849

EP - 8851

JO - Chemical Communications

JF - Chemical Communications

IS - 64

ER -

Negatively-charged helices in the gas phase

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