Negatively-charged helices in the gas phase

Andrew R. Johnson, Jonathan M. Dilger, Matthew S. Glover, David E. Clemmer, Erin E. Carlson

Research output: Contribution to journalArticle

6 Scopus citations


A polyalanine-based peptide which forms a stable, negatively-charged α-helix in the gas phase is reported. Addition of an N-terminal acidic residue forms a stabilizing hydrogen bond network and an electrostatic interaction with the helical dipole. Formation of this secondary structure was demonstrated using ion mobility-mass spectrometry and molecular modelling techniques. This journal is

Original languageEnglish (US)
Pages (from-to)8849-8851
Number of pages3
JournalChemical Communications
Issue number64
StatePublished - Aug 18 2014

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    Johnson, A. R., Dilger, J. M., Glover, M. S., Clemmer, D. E., & Carlson, E. E. (2014). Negatively-charged helices in the gas phase. Chemical Communications, 50(64), 8849-8851.