Negatively charged carbon nanohorn supported cationic liposome nanoparticles: A novel delivery vehicle for anti-nicotine vaccine

Hong Zheng, Yun Hu, Wei Huang, Sabina De Villiers, Paul Pentel, Jianfei Zhang, Harry Dorn, Marion Ehrich, Chenming Zhang

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

Tobacco addiction is the second-leading cause of death in the world. Due to the nature of nicotine (a small molecule), finding ways to combat nicotine's deleterious effects has been a constant challenge to the society and the medical field. In the present work, a novel anti-nicotine vaccine based on nanohorn supported liposome nanoparticles (NsL NPs) was developed. The nano-vaccine was constructed by using negatively charged carbon nanohorns as a scaffold for the assembly of cationic liposomes, which allow the conjugation of hapten conjugated carrier proteins. The assembled bio-nanoparticles are stable. Mice were immunized subcutaneously with the nano-vaccine, which induced high titer and high affinity of nicotine specific antibodies in mice. Furthermore, no evidence of clinical signs or systemic toxicity followed multiple administrations of NsL-based anti-nicotine vaccine. These results suggest that NsL-based anti-nicotine vaccine is a promising candidate in treating nicotine dependence and could have potential to significantly contribute to smoking cessation.

Original languageEnglish (US)
Pages (from-to)2197-2210
Number of pages14
JournalJournal of Biomedical Nanotechnology
Volume11
Issue number12
DOIs
StatePublished - Dec 1 2015

Bibliographical note

Publisher Copyright:
Copyright © 2015 American Scientific Publishers. All rights reserved.

Keywords

  • Anti-nicotine
  • Bionanoparticle
  • Carbon nanohorn
  • Nano-vaccine
  • Nicotine
  • Nicotine vaccine

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