Negative symptoms and the early course of schizophrenia

Janice A. Husted, Morton Beiser, William G. Iacono

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


To determine the usefulness of including a duration criterion in the definition of "negative" symptoms, the prognostic significance of a longitudinally obtained measure of negative symptoms was compared with a cross-sectionally obtained measure. As predicted, the presence of negative symptoms based on longitudinal observation was associated with most aspects of 18-month course in a group of "first-episode" schizophrenic individuals, whereas cross-sectional levels of negative symptoms were not. The findings suggest that negative symptoms, when operationalized as a trait-like phenomenon, help to portend a poor course of illness.

Original languageEnglish (US)
Pages (from-to)215-222
Number of pages8
JournalPsychiatry Research
Issue number3
StatePublished - Sep 1992


  • Prognosis
  • onset of illness
  • outcome
  • psychosis

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