Necrobiosis Lipoidica: An Immunofluorescence Study

Susanne Ullman, Mark V. Dahl

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78 Scopus citations


Biopsy specimens from 12 patients with necrobiosis lipoidica (diabeticorum) were studied by direct immunofluorescent microscopy. The immunoglobulin IgM was present in blood vessel walls of involved skin from six patients, and the third component of complement (C3) was present in the blood vessel walls of involved skin from seven patients. The immunoglobulin IgA was similarly observed in two patients. In addition, IgM, C3, or fibrinogen were observed at the dermal-epidermal junction of involved skin from seven patients. Necrobiotic areas invariably contained fibrinogen. These findings suggest that an immunecomplex vasculitis may be involved in the pathogenesis of necrobiosis lipoidica.

Original languageEnglish (US)
Pages (from-to)1671-1673
Number of pages3
JournalArchives of Dermatology
Issue number12
StatePublished - Dec 1977
Externally publishedYes

Bibliographical note

Funding Information:
Thisinvestigationwassupportedinpartbya grant from the Diabetes Research Fund of the AmericanDiabetesAssociation,MinnesotaAffil¬


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