NBQX, an improved non-NMDA antagonist studied in retinal ganglion cells

Weifeng Yu, Robert F. Miller

Research output: Contribution to journalArticlepeer-review

40 Scopus citations

Abstract

The quinoxaline derivative, 2,3-dihydroxy-6-nitro-7-sulfamoylbenzo (F) quinoxaline (NBQX), significantly reduced the currents evoked by exogenous application of quisqualate (QQ), kainate (KA) and α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) when applied to ganglion cells, using whole-cell recording in a slice preparation of the tiger salamander retina. A comparison between NBQX and CNQX indicates that NBQX is more effective in blocking AMPA receptors. Also, at up to 10 μM, NBQX has no effect on NMDA-induced currents. Thus at this concentration, NBQX shows no affinity for the glycine binding site of NMDA receptors. For this reason, NBQX is preferred over CNQX for a more effective and selective antagonism toward non-NMDA receptors.

Original languageEnglish (US)
Pages (from-to)190-194
Number of pages5
JournalBrain Research
Volume692
Issue number1-2
DOIs
StatePublished - Sep 18 1995

Keywords

  • CNQX
  • NBQX
  • NMDA and non-NMDA receptor
  • Retinal ganglion cell

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