TY - JOUR
T1 - NBQX, an improved non-NMDA antagonist studied in retinal ganglion cells
AU - Yu, Weifeng
AU - Miller, Robert F.
PY - 1995/9/18
Y1 - 1995/9/18
N2 - The quinoxaline derivative, 2,3-dihydroxy-6-nitro-7-sulfamoylbenzo (F) quinoxaline (NBQX), significantly reduced the currents evoked by exogenous application of quisqualate (QQ), kainate (KA) and α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) when applied to ganglion cells, using whole-cell recording in a slice preparation of the tiger salamander retina. A comparison between NBQX and CNQX indicates that NBQX is more effective in blocking AMPA receptors. Also, at up to 10 μM, NBQX has no effect on NMDA-induced currents. Thus at this concentration, NBQX shows no affinity for the glycine binding site of NMDA receptors. For this reason, NBQX is preferred over CNQX for a more effective and selective antagonism toward non-NMDA receptors.
AB - The quinoxaline derivative, 2,3-dihydroxy-6-nitro-7-sulfamoylbenzo (F) quinoxaline (NBQX), significantly reduced the currents evoked by exogenous application of quisqualate (QQ), kainate (KA) and α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) when applied to ganglion cells, using whole-cell recording in a slice preparation of the tiger salamander retina. A comparison between NBQX and CNQX indicates that NBQX is more effective in blocking AMPA receptors. Also, at up to 10 μM, NBQX has no effect on NMDA-induced currents. Thus at this concentration, NBQX shows no affinity for the glycine binding site of NMDA receptors. For this reason, NBQX is preferred over CNQX for a more effective and selective antagonism toward non-NMDA receptors.
KW - CNQX
KW - NBQX
KW - NMDA and non-NMDA receptor
KW - Retinal ganglion cell
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U2 - 10.1016/0006-8993(95)00665-D
DO - 10.1016/0006-8993(95)00665-D
M3 - Article
C2 - 8548303
AN - SCOPUS:0029023077
VL - 692
SP - 190
EP - 194
JO - Brain Research
JF - Brain Research
SN - 0006-8993
IS - 1-2
ER -