Naturligt forekommende nefrotisk syndrom hos hund er en potentiel hyperkoagulationstilstand

Translated title of the contribution: Naturally Occurring Canine Nephrotic Syndrome is a Potentially Hypercoagulable State

A. Rasedee, B. F. Feldman, R. Washabau

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Fourteen dogs with naturally occurring nephrotic syndrome were evaluated for abnormalities in the hemostatic system. Histopathologic diagnoses included 8 dogs with membraneous glomerulonephritis, 1 dog with acute glomerulon-ephritis, 2 dogs with idiopathic glomerulopathy, and 2 dogs with amyloidosis. The coagulation protein assays performed included concentrations of factors V, VII, VIII: C, IX, X, fibrinogen (I), anti-thrombin III, and plasminogen. Thrombocyte counts were also performed. All of these analytes were significantly elevated (P < 0.05) with the exception of ATIΠ which was significantly decreased (P < 0.05). Five of the dogs had histologic evidence and 1 dog had angiographic evidence of thrombosis and thromboembolism. Naturally occurring canine nephrotic syndrome thus represents a potentially hypercoagulable state and may serve as a valuable model in the study of certain components of the human disease.

Translated title of the contributionNaturally Occurring Canine Nephrotic Syndrome is a Potentially Hypercoagulable State
Original languageGerman
Pages (from-to)369-377
Number of pages9
JournalActa veterinaria Scandinavica
Volume27
Issue number3
DOIs
StatePublished - Sep 1986

Bibliographical note

Funding Information:
This work was supported, in part, through a National Institute of Health (USA), Public Health Service Biomedical Research Support Grant (84-15).

Keywords

  • antithrombin III
  • dog
  • hemostasis
  • hypercoagulation
  • thromboembolism
  • thrombosis

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