Natural products as leads for tuberculosis drug development

Christine E. Salomon, Lori E. Schmidt

Research output: Contribution to journalReview articlepeer-review

43 Scopus citations

Abstract

New therapeutics are urgently needed to combat the immense disease burden of tuberculosis and related mycobacterial diseases worldwide. Natural products continue to provide leads for the development of novel drugs to treat the rapidly growing numbers of patients with multi- and extensively-drug resistant tuberculosis. This review presents natural products and synthesized analogues with anti-mycobacterial activity published between 2006 through 2009. Structure activity relationships, synthetic analogues and newly reported activities of known compounds reported during this period are also included.

Original languageEnglish (US)
Pages (from-to)735-765
Number of pages31
JournalCurrent topics in medicinal chemistry
Volume12
Issue number7
DOIs
StatePublished - Apr 1 2012

Keywords

  • Drug development
  • Drug resistant tuberculosis
  • Mycobacterium tuberculosis
  • Natural products
  • Structure activity relationship
  • Tuberculosis

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