Natural product biosynthesis moves in vitro

Robert A. Fecik

Research output: Contribution to journalShort surveypeer-review

6 Scopus citations


Heterologous production of natural products in non-native bacteria can be used to increase yields of certain bioactive compounds; however, producing small molecules inside bacteria has numerous limitations. Two reports of the in vitro reconstruction of entire biosynthetic pathways highlight the advantages and challenges of this approach for pathway engineering.

Original languageEnglish (US)
Pages (from-to)531-532
Number of pages2
JournalNature Chemical Biology
Issue number9
StatePublished - Sep 2007


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