Natural Polymorphisms in Human APOBEC3H and HIV-1 Vif Combine in Primary T Lymphocytes to Affect Viral G-to-A Mutation Levels and Infectivity

Keyphrases

• Viral 100%
• T Cells 100%
• HIV-1 Vif 100%
• Infectivity 100%
• APOBEC3H 100%
• G-to-A mutations 100%
• Natural Polymorphism 100%
• APOBEC3 40%
• Human Immunodeficiency Virus Type 1 (HIV-1) 30%
• HyPer 20%
• Hypo 20%
• Lymphocytes 20%
• Virus Replication 20%
• Antiviral Activity 10%
• Virus 10%
• Polymorphism 10%
• Natural Variation 10%
• Overexpression 10%
• APOBEC3G 10%
• HIV-1 Infection 10%
• DNA Cytosine Deaminase 10%
• HIV-1 Replication 10%
• Protein Level 10%
• Hypermutation 10%
• Active Protein 10%
• Amino Acid Residues 10%
• CD4+ T Lymphocytes 10%
• Intrinsic Properties 10%
• Differential Resistance 10%
• Global Distribution 10%
• APOBEC3F 10%
• Evolutionary Equilibrium 10%
• Short Half-life 10%

Biochemistry, Genetics and Molecular Biology

• Human Immunodeficiency Virus 1 100%
• T Cell 100%
• Haplotype 50%
• Virus Replication 33%
• Lymphocyte 33%
• APOBEC3G 16%
• Amino Acids 16%
• Locus Control Region 16%
• APOBEC3F 16%
• Antiviral Activity 16%
• CD4 16%
• Cytosine Deaminase 16%

Immunology and Microbiology

• Human Immunodeficiency Virus 1 100%
• T Cell 100%
• Haplotype 50%
• Viral Replication 33%
• Lymphocyte 33%
• Virus 16%
• Regulator Gene 16%
• APOBEC3G 16%
• Antiviral Activity 16%
• CD4+ T Lymphocyte 16%
• Amino Acid 16%