Natural malaria infection in Anopheles gambiae is regulated by a single genomic control region

Michelle M. Riehle, Kyriacos Markianos, Oumou Niaré, Jiannong Xu, Jun Li, Abdoulaya M. Touré, Balco Podiougou, Frederick Oduol, Sory Diawara, Mouctar Diallo, Boubacar Coulibaly, Ahmad Ouatara, Leonid Kruglyak, Sékou F. Traoré, Kenneth D. Vernick

Research output: Contribution to journalReview articlepeer-review

218 Scopus citations


We surveyed an Anopheles gambiae population in a West African malaria transmission zone for naturally occurring genetic loci that control mosquito infection with the human malaria parasite, Plasmodium falciparum. The strongest Plasmodium resistance loci cluster in a small region of chromosome 2L and each locus explains at least 89% of parasite-free mosquitoes in independent pedigrees. Together, the clustered loci form a genomic Plasmodium-resistance island that explains most of the genetic variation for malaria parasite infection of mosquitoes in nature. Among the candidate genes in this chromosome region, RNA interference knockdown assays confirm a role in Plasmodium resistance for Anopheles Plasmodium-responsive leucine-rich repeat 1 (APL1), encoding a leucine-rich repeat protein that is similar to molecules involved in natural pathogen resistance mechanisms in plants and mammals.

Original languageEnglish (US)
Pages (from-to)577-579
Number of pages3
Issue number5773
StatePublished - Apr 28 2006


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