TY - JOUR
T1 - Natural killer cell adoptive transfer therapy
T2 - Exploiting the first line of defense against cancer
AU - Davis, Zachary B.
AU - Felices, Martin
AU - Verneris, Michael R.
AU - Miller, Jeffrey S.
N1 - Publisher Copyright:
© 2015 Wolters Kluwer Health, Inc. All rights reserved.
PY - 2015
Y1 - 2015
N2 - Natural killer (NK) cells constitute an important component of the initial immunological response against transformed cells. However, chronic exposure to the tumor microenvironment can fundamentally alter the ability of NK cells to sufficiently control tumor progression. Thus, the adoptive transfer of healthy, functional NK cells as an interventional therapy has been an area of great interest for improving patient outcomes. Recent developments in the field have provided a better understanding of what makes the NK compartment effective against malignant cells. Moreover, there are now multiple potential sources of NK cell products for infusion as well as techniques to manipulate these cells to enhance their antitumor functions. This review explores the advantages and disadvantages of various sources of NK cells as well as prospective therapeutic enhancements to adoptively transferred NK cells.
AB - Natural killer (NK) cells constitute an important component of the initial immunological response against transformed cells. However, chronic exposure to the tumor microenvironment can fundamentally alter the ability of NK cells to sufficiently control tumor progression. Thus, the adoptive transfer of healthy, functional NK cells as an interventional therapy has been an area of great interest for improving patient outcomes. Recent developments in the field have provided a better understanding of what makes the NK compartment effective against malignant cells. Moreover, there are now multiple potential sources of NK cell products for infusion as well as techniques to manipulate these cells to enhance their antitumor functions. This review explores the advantages and disadvantages of various sources of NK cells as well as prospective therapeutic enhancements to adoptively transferred NK cells.
KW - Adoptive transfer therapy
KW - Antitumor functions
KW - Prospective therapeutic enhancements
KW - Tumor microenvironment
KW - natural killer (NK) cells
UR - http://www.scopus.com/inward/record.url?scp=84948392976&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84948392976&partnerID=8YFLogxK
U2 - 10.1097/PPO.0000000000000156
DO - 10.1097/PPO.0000000000000156
M3 - Review article
C2 - 26588681
AN - SCOPUS:84948392976
SN - 1528-9117
VL - 21
SP - 486
EP - 491
JO - Cancer Journal (United States)
JF - Cancer Journal (United States)
IS - 6
ER -