Natural history of subaortic stenosis in 166 dogs (1999–2011)

B. D. Eason, D. M. Fine-Ferreira, D. Leeder, C. Stauthammer, K. Lamb, A. Tobias

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Introduction: Subaortic stenosis (SAS) is one of the most common congenital cardiac diseases in dogs. The objective of this study was to provide survival times on a large population of dogs with SAS and to propose a redefined pressure gradient (PG) scale to include a mild, moderate, severe and very severe disease group. Animals, materials and methods: Dogs were divided into four groups based on the Doppler-derived PG across the stenosis. Disease severity was defined as follows: mild = PG < 50 mmHg; moderate = PG range 50–80 mmHg; severe = PG range 80–130 mmHg; and very severe = PG > 130 mmHg. Over the study period (1999–2011), 166 client-owned dogs were diagnosed with SAS of which 129 had follow-up information available. Results: Unadjusted median survival time for severity groups were as follows: mild 10.6 years; moderate 9.9 years; severe 7.3 years; and very severe 3.0 years. Univariable analysis examining the effect of the PG, age at diagnosis and sex found only the PG and age at diagnosis had a significant effect on survival. Adjusted survival curves showed that the survival time in the very severe group was decreased compared with all other groups. Conclusion: Based on the results of this study, a revised SAS classification system with four PG groups is appropriate. Dogs with a PG > 130 mmHg were identified as those with the lowest median survival time.

Original languageEnglish (US)
Pages (from-to)71-80
Number of pages10
JournalJournal of Veterinary Cardiology
Early online dateSep 2 2021
StatePublished - Oct 2021

Bibliographical note

Funding Information:
The authors would like to thank Kristin Hohnadel BS, CVT, VTS (Cardiology) and Ed Durham CVT, LATG, VTS (Cardiology) for their technical assistance.

Publisher Copyright:
© 2021 Elsevier B.V.


  • Congenital heart disease
  • Disease classification
  • Echocardiogram
  • Survival time

PubMed: MeSH publication types

  • Journal Article


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