Natural antiband 3 antibodies in patients with sickle cell disease

Rinaldo Villaescusa, Ada Amalia Arce, Marie Laure Lalanne-Mistrih, Yann Lamarre, Régine Hierso, Carlos Hernández, Marie Dominique Hardy-Dessources

Research output: Contribution to journalShort surveypeer-review

7 Scopus citations

Abstract

Band 3 oligomers, precociously formed in the membrane of sickle red blood cells (SS RBC) as a result of oxidative damage, induce two significant changes: (1) contribution to the adhesive nature of these cells to endothelial cells; (2) production of recognition sites for natural antiband 3 antibodies (antiband 3 Nabs). The inhibition of the adhesion of SS RBC to endothelial cells by band 3 peptides suggests a participation of antiband 3 Nabsin the ethiology and prevention of vaso-occlusive crises (VOC). To address this question, we measured the levels of antiband 3 Nabsin sickle cell anaemia (SCA) patients (45 in steady state, 35 in VOC) and in controls (27 sickle trait, 30 normal AA subjects). A significant decreased of antiband 3 Nabs in the VOC group was demonstrated as compared with the steady state group, the sickle trait and healthy controls. This study provides data suggesting that Antiband 3 Nabs are likely to play a role in the SCA VOC.

Original languageEnglish (US)
Pages (from-to)173-176
Number of pages4
JournalComptes Rendus - Biologies
Volume336
Issue number3
DOIs
StatePublished - Mar 2013

Keywords

  • Band 3
  • Natural band 3 antibodies
  • Sickle cell disease
  • Vaso-occlusion

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