Natriuretic peptides modulate inner ear function

George J. Trachte, Janet L. Fitzakerley

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

Natriuretic peptides dramatically increase urine volume and sodium content by influencing renal transport mechanisms for sodium, potassium and chloride. Many of the identical transporters provide vital contributions to fluid and electrolyte balance in the cochlea of the inner ear. Recent results from experiments using knockout mouse models support the hypothesis that the natriuretic peptide pathway has a critical role in hearing. In this review, the components of the natriuretic peptide system known to be present in the inner ear and their ability to regulate the function of the cochlea will be detailed.

Original languageEnglish (US)
Title of host publicationNatriuretic Peptides
Subtitle of host publicationPhysiology, Molecular Biology, and Clinical Implications
PublisherNova Science Publishers, Inc.
Pages237-258
Number of pages22
ISBN (Electronic)9781633210837
ISBN (Print)9781633210806
StatePublished - Jul 1 2014

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