Abstract
Atrial natriuretic peptide, B-type natriuretic peptide and C-type natriuretic peptide constitute a family of three structurally related, but genetically distinct, signaling molecules that regulate the cardiovascular, skeletal, nervous, reproductive and other systems by activating transmembrane guanylyl cyclases and elevating intracellular cGMP concentrations. This review broadly discusses the general characteristics of natriuretic peptides and their cognate signaling receptors, and then specifically discusses the tissue-specific metabolism of natriuretic peptides and their degradation by neprilysin, insulin-degrading enzyme, and natriuretic peptide receptor-C. Natriuretic peptides are a family of three related pleiotropic signaling factors that bind and activate transmembrane guanylyl cyclases. This review initially discusses the general characteristics of natriuretic peptides and their receptors. The tissue specific metabolism of natriuretic peptides and their degradation by individual proteases and natriuretic peptide receptor C-mediated internalization are then more specifically discussed.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1808-1817 |
| Number of pages | 10 |
| Journal | FEBS Journal |
| Volume | 278 |
| Issue number | 11 |
| DOIs | |
| State | Published - Jun 1 2011 |
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Keywords
- ANF
- B-type natriuretic peptide (BNP)
- atrial natriuretic peptide (ANP)
- cGMP
- cardiovascular disease
- endochondrial ossification
- neprilysin
- proteolysis
- receptor internalization
Cite this
Natriuretic peptide metabolism, clearance and degradation. / Potter, Lincoln R.
In: FEBS Journal, Vol. 278, No. 11, 01.06.2011, p. 1808-1817.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Natriuretic peptide metabolism, clearance and degradation
AU - Potter, Lincoln R.
PY - 2011/6/1
Y1 - 2011/6/1
N2 - Atrial natriuretic peptide, B-type natriuretic peptide and C-type natriuretic peptide constitute a family of three structurally related, but genetically distinct, signaling molecules that regulate the cardiovascular, skeletal, nervous, reproductive and other systems by activating transmembrane guanylyl cyclases and elevating intracellular cGMP concentrations. This review broadly discusses the general characteristics of natriuretic peptides and their cognate signaling receptors, and then specifically discusses the tissue-specific metabolism of natriuretic peptides and their degradation by neprilysin, insulin-degrading enzyme, and natriuretic peptide receptor-C. Natriuretic peptides are a family of three related pleiotropic signaling factors that bind and activate transmembrane guanylyl cyclases. This review initially discusses the general characteristics of natriuretic peptides and their receptors. The tissue specific metabolism of natriuretic peptides and their degradation by individual proteases and natriuretic peptide receptor C-mediated internalization are then more specifically discussed.
AB - Atrial natriuretic peptide, B-type natriuretic peptide and C-type natriuretic peptide constitute a family of three structurally related, but genetically distinct, signaling molecules that regulate the cardiovascular, skeletal, nervous, reproductive and other systems by activating transmembrane guanylyl cyclases and elevating intracellular cGMP concentrations. This review broadly discusses the general characteristics of natriuretic peptides and their cognate signaling receptors, and then specifically discusses the tissue-specific metabolism of natriuretic peptides and their degradation by neprilysin, insulin-degrading enzyme, and natriuretic peptide receptor-C. Natriuretic peptides are a family of three related pleiotropic signaling factors that bind and activate transmembrane guanylyl cyclases. This review initially discusses the general characteristics of natriuretic peptides and their receptors. The tissue specific metabolism of natriuretic peptides and their degradation by individual proteases and natriuretic peptide receptor C-mediated internalization are then more specifically discussed.
KW - ANF
KW - B-type natriuretic peptide (BNP)
KW - atrial natriuretic peptide (ANP)
KW - cGMP
KW - cardiovascular disease
KW - endochondrial ossification
KW - neprilysin
KW - proteolysis
KW - receptor internalization
UR - http://www.scopus.com/inward/record.url?scp=79956194650&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79956194650&partnerID=8YFLogxK
U2 - 10.1111/j.1742-4658.2011.08082.x
DO - 10.1111/j.1742-4658.2011.08082.x
M3 - Review article
C2 - 21375692
AN - SCOPUS:79956194650
VL - 278
SP - 1808
EP - 1817
JO - FEBS Journal
JF - FEBS Journal
SN - 1742-464X
IS - 11
ER -